Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

DR Nässel, M Zandawala - Progress in neurobiology, 2019 - Elsevier
This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

A Model for Basic Emotions Using Observations of Behavior in Drosophila

S Gu, F Wang, NP Patel, JA Bourgeois… - Frontiers in …, 2019 - frontiersin.org
Emotion plays a crucial role, both in general human experience and in psychiatric illnesses.
Despite the importance of emotion, the relative lack of objective methodologies to …

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

DR Nässel, M Zandawala - Open Biology, 2022 - royalsocietypublishing.org
Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

Cell types and neuronal circuitry underlying female aggression in Drosophila

CE Schretter, Y Aso, AA Robie, M Dreher, MJ Dolan… - Elife, 2020 - elifesciences.org
Aggressive social interactions are used to compete for limited resources and are regulated
by complex sensory cues and the organism's internal state. While both sexes exhibit …

Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

AV Devineni, KM Scaplen - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses
based on changes in the environmental context, internal state, or experience. Studies in …

Rage Against the Machine: Advancing the study of aggression ethology via machine learning.

NL Goodwin, SRO Nilsson, SA Golden - Psychopharmacology, 2020 - Springer
Rationale Aggression, comorbid with neuropsychiatric disorders, exhibits with diverse
clinical presentations and places a significant burden on patients, caregivers, and society …

Dopamine modulation of sensory processing and adaptive behavior in flies

KP Siju, JF De Backer, IC Grunwald Kadow - Cell and tissue research, 2021 - Springer
Behavioral flexibility for appropriate action selection is an advantage when animals are
faced with decisions that will determine their survival or death. In order to arrive at the right …

A neuropeptide regulates fighting behavior in Drosophila melanogaster

F Wu, B Deng, N Xiao, T Wang, Y Li, R Wang, K Shi… - Elife, 2020 - elifesciences.org
Aggressive behavior is regulated by various neuromodulators such as neuropeptides and
biogenic amines. Here we found that the neuropeptide Drosulfakinin (Dsk) modulates …

Circuits that encode and guide alcohol-associated preference

KM Scaplen, M Talay, KM Nunez, S Salamon… - Elife, 2020 - elifesciences.org
A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive
substances can remold neural circuits important for memory to reduce this flexibility …

State-dependent plasticity of innate behavior in fruit flies

ICG Kadow - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Innate behaviors are plastic allowing behavioral adaptation depending on
context and need.•Hunger modulates innate odor preference through dopaminergic neurons …