Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Advanced glycation end products (AGEs) and their receptor have been implicated in the
progressions of many intractable diseases, such as diabetes and atherosclerosis, and are …

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

Inflammation has been described for two millennia, but cellular aspects and the paradigm
involving different mediators have been identified in the recent century. Two main groups of …

CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-
receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal …

Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal
models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive …

Inflammation is a protective response that develops against tissue injury and infection.
Chronic inflammation, on the other hand, is the key player in the pathogenesis of many …

The link between cancer and inflammation is specific transcription factors that once activated
have the capacity to enhance expression of genes that are common to both the regulation …

The immune system has evolved mechanisms to protect the host from the deleterious effects
of inflammation. The generation of immune suppressive cells like myeloid derived …