Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents

RJM Brüggemann, JWC Alffenaar… - Clinical Infectious …, 2009 - academic.oup.com
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely,
fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical …

Benzodiazepine metabolism: an analytical perspective

R Mandrioli, L Mercolini, MA Raggi - Current drug metabolism, 2008 - ingentaconnect.com
Benzodiazepines are currently among the most frequently prescribed drugs all over the
world. They act as anxiolytics, sedatives, hypnotics, amnesics, antiepileptics and muscle …

[HTML][HTML] Navigating the complex landscape of benzodiazepine-and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and …

F Koniuszewski, FD Vogel, I Dajić, T Seidel… - Frontiers in …, 2023 - frontiersin.org
Introduction Medications which target benzodiazepine (BZD) binding sites of GABAA
receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry …

Itraconazole and domperidone: a placebo-controlled drug interaction study

T Yoshizato, T Kotegawa, H Imai, K Tsutsumi… - European journal of …, 2012 - Springer
Purpose To determine the influence of itraconazole on the pharmacokinetics, and the CNS
and prolactin-elevating effects of domperidone in humans. Methods Fifteen healthy …

The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers

M Oda, T Kotegawa, K Tsutsumi, Y Ohtani… - European journal of …, 2003 - Springer
Rationale and objective Bromazepam, an anti-anxiety agent, has been reported to be
metabolized by cytochrome P 450 (CYP). However, the enzyme responsible for the …

咪达唑仑对人定量药物脑电图δ 频段功率百分比的影响

王立伟, 戴体俊, 王建华, 张党生, 周美艳 - 中国药理学通报, 2011 - cqvip.com
目的观察咪达唑仑对人定量药物脑电图(QPEEG) δ 频段功率百分比的影响. 方法青年志愿者20
人, 每组10 人, 均为男性, 分别静脉注射咪达唑仑0.05 mg. kg-1 (Ⅰ 组), 0.1 mg. kg-1 (Ⅱ 组) …

Drug interactions with benzodiazepines: epidemiologic correlates with other CNS depressants and in vitro correlates with inhibitors and inducers of cytochrome P450 …

DE Moody - Handbook of drug interactions: a clinical and forensic …, 2012 - Springer
The benzodiazepines are a class of a relatively large number of drugs that share a common
chemical structure and have anxiolytic to sedative action on the central nervous system …

Development and validation of an HPLC method for the simultaneous monitoring of bromazepam and omeprazole

G Podilsky, M Berger‐Gryllaki, B Testa… - Journal of liquid …, 2008 - Taylor & Francis
Bromazepam and omeprazole are frequently administered to hospitalized patients to
decrease anxiety and prevent stress ulcers, respectively. In patients under enteral nutrition …

芬太尼对兔定量药物脑电图β_2 频段功率百分比的影响

李贺, 赵健, 韦慧, 李洪哲, 韩平平, 戴体俊, 邵东华… - 中国药理学通报, 2013 - cqvip.com
目的探讨芬太尼对兔定量药物脑电图(QPEEG) β2 频段功率的影响及其与阿片受体的关系.
方法36 只家兔, 分6 组(n= 6): NS 组(生理盐水1 ml· kg-1), NA 组(纳洛酮200 μg· kg-1), LD …

Progress in the consideration of possible sex differences in drug interaction studies

P Naidoo, M Chetty - Current drug metabolism, 2019 - ingentaconnect.com
Background: Anecdotal evidence suggests that there may be sex differences in Drug-drug
Interactions (DDI) involving specific drugs. Regulators have provided general guidance for …