Calcineurin inhibitors (CNIs) are drugs that inhibit calcineurin, a key phosphatase that
dephosphorylates a transcription factor called the nuclear factor of activated T cells (NFAT) …

Transforming growth factor-β (TGF-β) functions as an immune suppressor by influencing
immune cells' development, differentiation, tolerance induction and homeostasis. In human …

Cell reprogramming concepts have been classically developed in the fields of
developmental and stem cell biology and are currently being explored for regenerative …

Epitope peptides are not suitable for nasal administration immunity due to their poor
immunogenicity and low delivery efficiency. Here, we reported an intranasal self-assembled …

Tumor-derived autophagosomes (DRibble) selectively capture tumor-specific antigens and
induce a dramatic T-cell activation and expansion when injected into lymph nodes of naive …

Engineered chimeric cytokines can generate gain-of-function activity in immune cells. Here,
we report potent antitumor activity for a novel fusion cytokine generated by N-terminal …

Controversial views regarding the roles of B cells in tumor immunity have existed for several
decades. However, more recent studies have focused on its positive properties in antitumor …

Fusokines are chimeric proteins generated by the physical coupling of cytokines in a single
polypeptide, resulting in proteins with highly pleiotropic activity and the potential to treat …

Activated B-cells are a promising alternative source of antigen-presenting cells. They can
generally be obtained in sufficient numbers for clinical use, but in most instances produce …

目的评价Wilm 瘤基因1 (Wilms' tumor gene1, WT1) 多肽联合AddaVax TM
乳佐剂疫苗的稳定性, 安全性, 免疫增强效应及其对急性髓系白血病抗肿瘤效应. 方法用MALDI …