Blood-brain barrier dysfunction and recovery after ischemic stroke

X Jiang, AV Andjelkovic, L Zhu, T Yang… - Progress in …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Human astrocytes: structure and functions in the healthy brain

F Vasile, E Dossi, N Rouach - Brain Structure and Function, 2017 - Springer
Data collected on astrocytes' physiology in the rodent have placed them as key regulators of
synaptic, neuronal, network, and cognitive functions. While these findings proved highly …

[HTML][HTML] Astrocytic activation generates de novo neuronal potentiation and memory enhancement

A Adamsky, A Kol, T Kreisel, A Doron… - Cell, 2018 - cell.com
Astrocytes respond to neuronal activity and were shown to be necessary for plasticity and
memory. To test whether astrocytic activity is also sufficient to generate synaptic potentiation …

Astrocyte activation in neurovascular damage and repair following ischaemic stroke

A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

[HTML][HTML] Human astrocytes in the diseased brain

E Dossi, F Vasile, N Rouach - Brain research bulletin, 2018 - Elsevier
Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Reactive glia inflammatory signaling pathways and epilepsy

P Sanz, MA Garcia-Gimeno - International journal of molecular sciences, 2020 - mdpi.com
Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal
hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function …

[HTML][HTML] Astrocytes: a double-edged sword in neurodegenerative diseases

ZB Ding, LJ Song, Q Wang, G Kumar… - Neural regeneration …, 2021 - journals.lww.com
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the
central nervous system by regulating homeostasis, increasing synaptic plasticity, and …

[HTML][HTML] An overview on the differential interplay among neurons–astrocytes–microglia in CA1 and CA3 hippocampus in hypoxia/ischemia

D Lana, F Ugolini, MG Giovannini - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Neurons have been long regarded as the basic functional cells of the brain, whereas
astrocytes and microglia only as elements of support. However, proper intercommunication …