[HTML][HTML] Immune checkpoint inhibitors: Key trials and an emerging role in breast cancer
N Gaynor, J Crown, DM Collins - Seminars in cancer biology, 2022 - Elsevier
This review focuses on immune checkpoint inhibitors–immunomodulatory agents that aim to
relieve tumour-mediated immune-cell suppression. Immune checkpoint proteins can be …
relieve tumour-mediated immune-cell suppression. Immune checkpoint proteins can be …
Humanized mice for the study of immuno-oncology
P De La Rochere, S Guil-Luna, D Decaudin, G Azar… - Trends in …, 2018 - cell.com
Immunotherapy is revolutionizing cancer treatment; however, complete responses are
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …
Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial
M Gogishvili, T Melkadze, T Makharadze… - Nature medicine, 2022 - nature.com
First-line cemiplimab (anti-programmed cell death-1 (PD-1)) monotherapy has previously
shown significant improvement in overall survival (OS) and progression-free survival (PFS) …
shown significant improvement in overall survival (OS) and progression-free survival (PFS) …
Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3 …
A Sezer, S Kilickap, M Gümüş, I Bondarenko… - The Lancet, 2021 - thelancet.com
Background We aimed to examine cemiplimab, a programmed cell death 1 inhibitor, in the
first-line treatment of advanced non-small-cell lung cancer with programmed cell death …
first-line treatment of advanced non-small-cell lung cancer with programmed cell death …
PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma
MR Migden, D Rischin, CD Schmults… - … England Journal of …, 2018 - Mass Medical Soc
Background No systemic therapies have been approved for the treatment of advanced
cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy …
cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy …
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial
MR Migden, NI Khushalani, ALS Chang… - The lancet …, 2020 - thelancet.com
Background Cemiplimab has shown substantial antitumour activity in patients with
metastatic cutaneous squamous cell carcinoma. Patients with locally advanced cutaneous …
metastatic cutaneous squamous cell carcinoma. Patients with locally advanced cutaneous …
[HTML][HTML] Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight …
D Rischin, MR Migden, AM Lim… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Original research: Phase 2 study of cemiplimab in patients with metastatic cutaneous
squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based …
squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based …
[HTML][HTML] Integrated analysis of a phase 2 study of cemiplimab in advanced cutaneous squamous cell carcinoma: extended follow-up of outcomes and quality of life …
D Rischin, NI Khushalani, CD Schmults… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background To provide pooled longer term data from three groups of a phase 2 study of
cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC), and to …
cemiplimab in patients with advanced cutaneous squamous cell carcinoma (CSCC), and to …
Cemiplimab: first global approval
A Markham, S Duggan - Drugs, 2018 - Springer
Cemiplimab (LIBTAYO®; cemiplimab-rwlc), a human programmed death receptor-1 (PD-1)
monoclonal antibody that binds to PD-1 and blocks its interaction with programmed death …
monoclonal antibody that binds to PD-1 and blocks its interaction with programmed death …
Molecular mechanisms of cutaneous squamous cell carcinoma
Non-melanoma skin cancers are cutaneous malignancies representing the most common
form of cancer in the United States. They are comprised predominantly of basal cell …
form of cancer in the United States. They are comprised predominantly of basal cell …