Early recognition of osteoporosis in children and adolescents is important in order to
establish an appropriate diagnosis of the underlying condition and to initiate treatment if …

To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide
the needed physical and mechanical properties for load-bearing applications. Although …

Bone mineralization entails two mineralization phases: primary and secondary
mineralization. Primary mineralization is achieved when matrix vesicles are secreted by …

Transcortical vessels (TCVs) provide effective communication between bone marrow
vascular system and external circulation. Although osteocytes are in close contact with them …

Proteoglycans consist of core proteins and one or more covalently-linked
glycosaminoglycan chains. They are structurally complex and heterogeneous …

Systemic application of glucocorticoids is an essential anti-inflammatory and immune-
modulating therapy for severe inflammatory or autoimmunity conditions. However, its long …

ABSTRACT Early‐onset osteoporosis (EOOP), characterized by low bone mineral density
(BMD) and fractures, affects children, premenopausal women and men aged< 50 years …

Research background The role of osteocytes in maintaining bone mass has been
progressively emphasized. Pip5k1c is the most critical isoform among PIP5KIs, which can …

Abstract Background Bisphosphonates (BPs) are widely used to inhibit excessive osteoclast
activity. However, the potential to compromise bone defect healing has limited their broader …

Recent years have witnessed an evolution of imaging technologies towards sophisticated
approaches for visualising cells within their natural environment (s) and for investigating …