Brain glucose metabolism: integration of energetics with function
GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
Physiology of astroglia
A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
[HTML][HTML] The science and translation of lactate shuttle theory
GA Brooks - Cell metabolism, 2018 - cell.com
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …
continuously under aerobic conditions. Shuttling between producer and consumer cells …
Lactate in the brain: from metabolic end-product to signalling molecule
PJ Magistretti, I Allaman - Nature reviews neuroscience, 2018 - nature.com
Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …
evidence shows that it can be found there under physiological conditions. In the brain …
Lactate in contemporary biology: a phoenix risen
After a century, it's time to turn the page on understanding of lactate metabolism and
appreciate that lactate shuttling is an important component of intermediary metabolism in …
appreciate that lactate shuttling is an important component of intermediary metabolism in …
A cellular perspective on brain energy metabolism and functional imaging
PJ Magistretti, I Allaman - Neuron, 2015 - cell.com
The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
Brain energy and oxygen metabolism: emerging role in normal function and disease
Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
Neuronal stimulation triggers neuronal glycolysis and not lactate uptake
CM Díaz-García, R Mongeon, C Lahmann, D Koveal… - Cell metabolism, 2017 - cell.com
Proper brain function requires a substantial energy supply, up to 20% of whole-body energy
in humans, and brain activation produces large dynamic variations in energy demand. While …
in humans, and brain activation produces large dynamic variations in energy demand. While …
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
G Yellen - Journal of Cell Biology, 2018 - rupress.org
The brain's energy demands are remarkable both in their intensity and in their moment-to-
moment dynamic range. This perspective considers the evidence for Warburg-like aerobic …
moment dynamic range. This perspective considers the evidence for Warburg-like aerobic …
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …