Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] The science and translation of lactate shuttle theory

GA Brooks - Cell metabolism, 2018 - cell.com
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Lactate in the brain: from metabolic end-product to signalling molecule

PJ Magistretti, I Allaman - Nature reviews neuroscience, 2018 - nature.com
Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Lactate in contemporary biology: a phoenix risen

GA Brooks, JA Arevalo, AD Osmond… - The Journal of …, 2022 - Wiley Online Library
After a century, it's time to turn the page on understanding of lactate metabolism and
appreciate that lactate shuttling is an important component of intermediary metabolism in …

A cellular perspective on brain energy metabolism and functional imaging

PJ Magistretti, I Allaman - Neuron, 2015 - cell.com
The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …

Brain energy and oxygen metabolism: emerging role in normal function and disease

ME Watts, R Pocock, C Claudianos - Frontiers in molecular …, 2018 - frontiersin.org
Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …

Neuronal stimulation triggers neuronal glycolysis and not lactate uptake

CM Díaz-García, R Mongeon, C Lahmann, D Koveal… - Cell metabolism, 2017 - cell.com
Proper brain function requires a substantial energy supply, up to 20% of whole-body energy
in humans, and brain activation produces large dynamic variations in energy demand. While …

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

G Yellen - Journal of Cell Biology, 2018 - rupress.org
The brain's energy demands are remarkable both in their intensity and in their moment-to-
moment dynamic range. This perspective considers the evidence for Warburg-like aerobic …

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …