Gamma-aminobutyric acid signaling in damage response, metabolism, and disease

K Kim, H Yoon - International Journal of Molecular Sciences, 2023 - mdpi.com
Gamma-aminobutyric acid (GABA) plays a crucial role in signal transduction and can
function as a neurotransmitter. Although many studies have been conducted on GABA in …

[HTML][HTML] The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: a critical reappraisal

HM Al-Kuraishy, NR Hussian, MS Al-Naimi… - … Journal of Preventive …, 2021 - ncbi.nlm.nih.gov
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …

MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

D Zhang, Y Wu, Z Li, H Chen, S Huang, C Jian… - Journal of …, 2021 - Springer
Background Patients with diabetes have an increased risk of nonunion and delayed union of
fractures. Macrophages have been shown as a key player in diabetic complications …

[HTML][HTML] Effects of γ-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial

TH de Bie, RF Witkamp, MGJ Balvers… - The American Journal of …, 2023 - Elsevier
Background Gamma-aminobutyric acid (GABA) is mainly known as an endogenously
produced neurotransmitter. However, GABA intake from dietary sources like tomatoes and …

Exosomes derived from adipose stem cells enhance bone fracture healing via the activation of the Wnt3a/β-catenin signaling pathway in rats with type 2 diabetes …

D Zhang, W Xiao, C Liu, Z Wang, Y Liu, Y Yu… - International Journal of …, 2023 - mdpi.com
Nonunion and delayed union are common complications of diabetes mellitus that pose a
serious health threat to people. There are many approaches that have been used to improve …

An anthracene-based hydrogen-bonded organic framework as a bifunctional fluorescent sensor for the detection of γ-aminobutyric acid and nitrofurazone

Y Liu, X Xu, B Yan - Inorganic Chemistry Frontiers, 2022 - pubs.rsc.org
Intelligent fluorescence detection for disease diagnosis has become a research hotspot. In
the era of big data, machine learning (ML) for analyzing data and mining will be widely used …

Physiological processes modulated by the chloride-sensitive WNK-SPAK/OSR1 kinase signaling pathway and the cation-coupled chloride cotransporters

AR Murillo-de-Ozores, M Chávez-Canales… - Frontiers in …, 2020 - frontiersin.org
The role of Cl–as an intracellular signaling ion has been increasingly recognized in recent
years. One of the currently best described roles of Cl–in signaling is the modulation of the W …

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Z Wang, L Bian, C Mo, H Shen, LJ Zhao, KJ Su… - Communications …, 2020 - nature.com
Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only
detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers …

Development of Janus particles as potential drug delivery systems for diabetes treatment and antimicrobial applications

KX Tan, MK Danquah, J Jeevanandam, A Barhoum - Pharmaceutics, 2023 - mdpi.com
Janus particles have emerged as a novel and smart material that could improve
pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two …

GABA promotes β‐cell proliferation, but does not overcome impaired glucose homeostasis associated with diet‐induced obesity

A Untereiner, S Abdo, A Bhattacharjee… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT γ‐Aminobutyric acid (GABA) administration has been shown to increase β‐cell
mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has any effect on β …