Cancer immunotherapy is a groundbreaking strategy that has revolutionized the field of
oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or …

In the presence of tissue inflammation, injury, or cancer, myeloid cells are recruited to
disease regions through a multi-step process involving myelopoiesis, chemotaxis, cell …

The tumor microenvironment (TME) plays an important role in various stages of tumor
generation, metastasis, and evasion of immune monitoring and treatment. TME targeted …

Introduction Receptor/ligand pair immune checkpoints are inhibitors that regulate immunity
as vital “Don't Find-Me” signals to the adaptive immune system, additionally, the essential …

Precise targeting is a major prerequisite for effective cancer therapy because it ensures a
sufficient therapeutic dosage in tumors while minimizing off-target side effects. Herein, we …

Background and Aims: The macrophage “don't eat me” pathway CD47/SIRPα is a target for
promising new immunotherapy. We hypothesized that a soluble variant of SIRPα is present …

Background Implant infections caused by biofilm forming bacteria are a major threat in
orthopedic surgery. Delivering antibiotics directly to an implant affected by a bacterial biofilm …

The use of treatments, such as programmed death protein 1 (PD1) or cytotoxic T lymphocyte-
associated antigen 4 (CTLA-4) antibodies, that loosen the natural checks upon immune cell …

Interphase nuclear rupture is a known driver of DNA damage and may ultimately lead to
genetic instability promoting cell dysfunction and cancer progression. As the structural …