Over the past three decades DNA has emerged as an exceptional molecular building block
for nanoconstruction due to its predictable conformation and programmable intra-and …

In vitro display technologies, best exemplified by phage and yeast display, were first
described for the selection of antibodies some 20 years ago. Since then, many antibodies …

R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …

Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific
immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells. Desensitization with …

Spinach is an in vitro–selected RNA aptamer that binds a GFP-like ligand and activates its
green fluorescence. Spinach is thus an RNA analog of GFP and has potentially widespread …

Introduction: Nucleic acid-based vaccines are being developed as a means to combine the
positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid …

RNA engineering for nanotechnology and medical applications is an exciting emerging
research field. RNA has intrinsically defined features on the nanometre scale and is a …

Coded ribosomal peptide synthesis could not have evolved unless its sequence and amino
acid–specific aminoacylated tRNA substrates already existed. We therefore wondered …

Combinatorial libraries built with severely restricted chemical diversity have yielded highly
functional synthetic binding proteins. Structural analyses of these minimalist binding sites …

KcsA is a proton-activated, voltage-modulated K+ channel that has served as the archetype
pore domain in the Kv channel superfamily. Here, we have used synthetic antigen-binding …