From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

Conotoxins: chemistry and biology

AH Jin, M Muttenthaler, S Dutertre, SWA Himaya… - Chemical …, 2019 - ACS Publications
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

[HTML][HTML] Peptide therapeutics from venom: Current status and potential

MW Pennington, A Czerwinski, RS Norton - Bioorganic & medicinal …, 2018 - Elsevier
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

SLC6 neurotransmitter transporters: structure, function, and regulation

AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Application of marine natural products in drug research

WY Lu, HJ Li, QY Li, YC Wu - Bioorganic & medicinal chemistry, 2021 - Elsevier
New diseases are emerging as the environment changes, so drug manufacturers are always
on the lookout for new resources to develop effective and safe drugs. In recent years, many …

Venoms as a platform for human drugs: translating toxins into therapeutics

GF King - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …

Conus venom peptide pharmacology

RJ Lewis, S Dutertre, I Vetter, MDJ Christie - Pharmacological reviews, 2012 - ASPET
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Discovery, synthesis, and structure–activity relationships of conotoxins

KB Akondi, M Muttenthaler, S Dutertre, Q Kaas… - Chemical …, 2014 - ACS Publications
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

DJ Newman, GM Cragg - Marine drugs, 2014 - mdpi.com
The marine habitat has produced a significant number of very potent marine-derived agents
that have the potential to inhibit the growth of human tumor cells in vitro and, in a number of …

Drugs and drug candidates from marine sources: An assessment of the current “state of play”

DJ Newman, GM Cragg - Planta medica, 2016 - thieme-connect.com
The potential of the marine environment to produce candidate compounds (structures) as
leads to, or even direct drugs from, has been actively discussed for the last 50 or so years …