The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …

Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

Emerging microbe infections, such as Zika virus (ZIKV), pose an increasing threat to human
health. Investigations on ZIKV replication have revealed the construction of replication …

Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …

Most drugs used to treat viral disease target a virus-coded product. They inhibit a single
virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals …

Enterovirus infections have become a serious public health threat to young children, leading
to hand-foot-and-mouth disease and more severe nervous system diseases. Due to the lack …

Global warming is changing the distribution of different pathogens around the globe, and
humans are more susceptible to new or re-emerging infections. The human response to …

Dengue virus (DENV) is the causative pathogen in the life-threatening dengue hemorrhagic
fever and dengue shock syndrome. DENV is transmitted to humans via the bite of an …

Dengue fever is a common arbovirus disease, which has been spread to the entire tropical
world. At present, effective drugs for the treatment of dengue fever have not yet appeared …