Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-
post-translational modifiers function as the final arbitrators of a protein substrate's …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

Abstract Cyclin-dependent kinase 9 (CDK9) is a member of the cyclin-dependent kinase
(CDK) family which is involved in transcriptional regulation of several genes, including the …

CRISPR-based cancer dependency maps are accelerating advances in cancer precision
medicine, but adequate functional maps are limited to the most common oncogenes. To …

Usp9x was recently shown to be highly expressed in myeloma patients with short
progression-free survival and is proposed to enhance stability of the survival protein Mcl-1 …

Intrinsic and acquired resistance to targeted therapies is a significant clinical problem in
cancer. We previously showed that resistance to regorafenib, a multi-kinase inhibitor for …

The anticancer properties of cruciferous vegetables are well known and attributed to an
abundance of isothiocyanates such as benzyl isothiocyanate (BITC) and phenethyl …