Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …

We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …

Trajectory inference approaches analyze genome-wide omics data from thousands of single
cells and computationally infer the order of these cells along developmental trajectories …

Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the
study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital …

Background Single-cell transcriptomics allows researchers to investigate complex
communities of heterogeneous cells. It can be applied to stem cells and their descendants in …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Measurement of the transcriptomes of single cells has been feasible for only a few years, but
it has become an extremely popular assay. While many types of analysis can be carried out …

The Human Cell Atlas: from vision to reality | Nature Skip to main content Thank you for visiting
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