The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

There has been a recent increase in the prevalence of asthma worldwide; however, the 5–
10% of patients with severe disease account for a substantial proportion of the health costs …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Concepts of asthma severity and control are important in the evaluation of patients and their
response to treatment but the terminology is not standardised and the terms are often used …

Abstract Analysis of patterns of variation of time-series, termed variability analysis,
represents a rapidly evolving discipline with increasing applications in different fields of …

Rationale: Corticosteroids (CSs) are the most effective asthma therapy, but responses are
heterogeneous and systemic CSs lead to long-term side effects. Therefore, an improved …

We propose an innovative, integrated, cost-effective health system to combat major non-
communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic …

Asthma is a complex disease, and its incidence is determined by an intricate interplay of
genetic and environmental factors. The identification of novel genes for asthma suggests …

In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory
response to early life exposures or events. Interactions between infections, atopy, genetic …