Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue
that affects about 462 million people, specific underlying determinants of insulin resistance …

Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …