Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino - Nature reviews Drug discovery, 2016 - nature.com
Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
FGF19 and FGF21 for the treatment of NASH—two sides of the same coin? Differential and overlapping effects of FGF19 and FGF21 from mice to human
E Henriksson, B Andersen - Frontiers in Endocrinology, 2020 - frontiersin.org
FGF19 and FGF21 analogues are currently in clinical development for the potential
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
S Talukdar, Y Zhou, D Li, M Rossulek, J Dong… - Cell metabolism, 2016 - cell.com
FGF21 plays a central role in energy, lipid, and glucose homeostasis. To characterize the
pharmacologic effects of FGF21, we administered a long-acting FGF21 analog, PF …
pharmacologic effects of FGF21, we administered a long-acting FGF21 analog, PF …
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
Summary Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator.
Exogenous FGF21 produces beneficial metabolic effects in animal models; however, the …
Exogenous FGF21 produces beneficial metabolic effects in animal models; however, the …
FGF21 gene therapy as treatment for obesity and insulin resistance
V Jimenez, C Jambrina, E Casana… - EMBO molecular …, 2018 - embopress.org
Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently
available therapies are not suited for all patients in the heterogeneous obese/T2D …
available therapies are not suited for all patients in the heterogeneous obese/T2D …
FGF21 regulates metabolism through adipose-dependent and-independent mechanisms
FGF21 is an endocrine hormone that regulates energy homeostasis and insulin sensitivity.
The mechanism of FGF21 action and the tissues responsible for these effects have been …
The mechanism of FGF21 action and the tissues responsible for these effects have been …
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
WL Holland, AC Adams, JT Brozinick, HH Bui… - Cell metabolism, 2013 - cell.com
FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as
a regulator of metabolism and energy utilization. However, the exact mechanism (s) …
a regulator of metabolism and energy utilization. However, the exact mechanism (s) …
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
Y Li, K Wong, A Giles, J Jiang, JW Lee, AC Adams… - Gastroenterology, 2014 - Elsevier
Background & Aims The hepatocyte-derived hormone fibroblast growth factor 21 (FGF21) is
a hormone-like regulator of metabolism. The nicotinamide adenine dinucleotide–dependent …
a hormone-like regulator of metabolism. The nicotinamide adenine dinucleotide–dependent …
[HTML][HTML] The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
FGF21 is a multifunctional metabolic regulator. The co-factor βKlotho (KLB) allows FGF21 to
signal via FGF receptors. Given the widespread nature of FGFR expression and KLB …
signal via FGF receptors. Given the widespread nature of FGFR expression and KLB …
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
UCP1-Tg mice with ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle
(SM) are a model of improved substrate metabolism and increased longevity. Analysis of …
(SM) are a model of improved substrate metabolism and increased longevity. Analysis of …