The cell biology of synapse formation
TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …
information during transfer. The diverse computational properties of synapses are shaped by …
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …
development and specifying neural circuit properties via the formation of multifarious …
3D printed chitosan/polycaprolactone scaffold for lung tissue engineering: hope to be useful for COVID-19 studies
To prevent or reduce mortality from lung diseases, new biological materials and scaffolds
are needed to conduct more accurate research and support lung tissue regeneration. On the …
are needed to conduct more accurate research and support lung tissue regeneration. On the …
Criss‐crossing autism spectrum disorder and adult neurogenesis
F Bicker, L Nardi, J Maier, V Vasic… - Journal of …, 2021 - Wiley Online Library
Autism spectrum disorder (ASD) comprises a group of multifactorial neurodevelopmental
disorders primarily characterized by deficits in social interaction and repetitive behavior …
disorders primarily characterized by deficits in social interaction and repetitive behavior …
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
N Wang, B Zhu, MA Allnutt… - Proceedings of the …, 2024 - National Acad Sciences
Synapse maintenance is essential for generating functional circuitry, and decrement in this
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …
process is a hallmark of neurodegenerative disease. Yet, little is known about synapse …
The γ-protocadherins interact physically and functionally with neuroligin-2 to negatively regulate inhibitory synapse density and are required for normal social …
Cell adhesion molecules (CAMs) are key players in the formation of neural circuits during
development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg …
development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg …
The roles of Par3, Par6, and aPKC polarity proteins in normal neurodevelopment and in neurodegenerative and neuropsychiatric disorders
L Zhang, X Wei - Journal of Neuroscience, 2022 - Soc Neuroscience
Normal neural circuits and functions depend on proper neuronal differentiation, migration,
synaptic plasticity, and maintenance. Abnormalities in these processes underlie various …
synaptic plasticity, and maintenance. Abnormalities in these processes underlie various …
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Copy number variations at 7q11. 23 cause neurodevelopmental disorders with shared and
opposite manifestations. Deletion causes Williams-Beuren syndrome featuring …
opposite manifestations. Deletion causes Williams-Beuren syndrome featuring …
Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3
Hearing depends on precise synaptic transmission between cochlear inner hair cells and
spiral ganglion neurons through afferent ribbon synapses. Neuroligins (Nlgns) facilitate …
spiral ganglion neurons through afferent ribbon synapses. Neuroligins (Nlgns) facilitate …
Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship
Y Zhu, Q Hui, Z Zhang, H Fu, Y Qin… - Journal of …, 2024 - Wiley Online Library
Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …