Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

Efflux pumps are a serious challenge for the development of antibacterial agents.
Overcoming efflux requires an in-depth understanding of efflux pump functions, specificities …

Gram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the
permeability barrier formed by their cell envelope. The complex and synergistic interplay of …

Novel drugs are needed to treat a variety of persistent diseases caused by intracellular
bacterial pathogens. Virulence pathways enable many functions required for the survival of …

Gram-negative bacteria cause the majority of critically drug-resistant infections,
necessitating the rapid development of new drugs with Gram-negative activity. However …

Tioconazole is an effective antifungal agent, which has a very low solubility in aqueous
media, that limits its bioavailability and efficacy. In an effort to overcome the drug limitations …

In the search for much-needed new antibacterial chemical matter, a myriad of compounds
have been reported in academic and pharmaceutical screening endeavors. Only a small …

The outer membrane (OM) of Gram-negative bacteria is the most difficult obstacle for small-
molecule antibiotics to reach their targets in the cytosol. The molecular features of Gram …

The Escherichia coli outer membrane channel TolC complexes with several inner
membrane efflux pumps to export compounds across the cell envelope. All components of …