Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
Physical stability and dissolution behaviors of amorphous pharmaceutical solids: Role of surface and interface effects
Q Shi, SM Moinuddin, Y Wang, F Ahsan, F Li - International Journal of …, 2022 - Elsevier
Amorphous pharmaceutical solids (APS) are single-or multi-component systems in which
drugs exist in high-energy states with long-range disordered molecular packing. APSs have …
drugs exist in high-energy states with long-range disordered molecular packing. APSs have …
Anisotropic molecular organization at a liquid/vapor interface promotes crystal nucleation with polymorph selection
The molecules at the surface of a liquid have different organization and dynamics from those
in the bulk, potentially altering the rate of crystal nucleation and polymorphic selection, but …
in the bulk, potentially altering the rate of crystal nucleation and polymorphic selection, but …
Impact of crystal nuclei on dissolution of amorphous drugs
Amorphous drugs are used to improve bioavailability of poorly water-soluble drugs.
Crystallization must be managed to take full advantage of this formulation strategy …
Crystallization must be managed to take full advantage of this formulation strategy …
[HTML][HTML] Surface-enhanced crystal nucleation and polymorph selection in amorphous posaconazole
Molecules at a liquid/vapor interface have different organizations and mobilities from those
in the bulk. These differences potentially influence the rate of crystal nucleation, but the …
in the bulk. These differences potentially influence the rate of crystal nucleation, but the …
Amorphous drug–polymer salts: Maximizing proton transfer to enhance stability and release
An amorphous drug–polymer salt (ADPS) can be remarkably stable against crystallization at
high temperature and humidity (eg, 40° C/75% RH) and provide fast release. Here, we …
high temperature and humidity (eg, 40° C/75% RH) and provide fast release. Here, we …
Drug release from surfactant-containing amorphous solid dispersions: mechanism and role of surfactant in release enhancement
Purpose To understand how surfactants affect drug release from ternary amorphous solid
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
Surfactants accelerate crystallization of amorphous nifedipine by similar enhancement of nucleation and growth independent of hydrophilic–lipophilic balance
Amorphous formulations, increasingly employed to deliver poorly soluble drugs, generally
contain surfactants to improve wetting and dissolution. These surfactants are often liquids …
contain surfactants to improve wetting and dissolution. These surfactants are often liquids …
Formulation and processing strategies which underpin susceptibility to matrix crystallization in amorphous solid dispersions
Through matrix crystallization, an amorphous solid may transform directly into its more stable
crystalline state, reducing the driving force for dissolution. Herein, the mechanism of matrix …
crystalline state, reducing the driving force for dissolution. Herein, the mechanism of matrix …
Amorphous drug–polymer salt with high stability under tropical conditions and fast dissolution: the challenging case of lumefantrine-PAA
Abstract Lumefantrine (LMF), a high-mobility and easy-to-crystallize WHO drug for treating
malaria, can form an amorphous salt with poly (acrylic acid)(PAA) that is remarkably stable …
malaria, can form an amorphous salt with poly (acrylic acid)(PAA) that is remarkably stable …