Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

State of the art techniques have been developed to isolate and analyze cells from various
tissues, aiming to capture their in vivo state. However, the majority of cell isolation protocols …

De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …

An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive
complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms …

Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible
gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for …

The induced expansion of tumor‐initiating cells (T‐ICs) upon repeated exposure of tumors to
chemotherapeutic drugs forms a major cause for chemoresistance and cancer metastasis …