[HTML][HTML] Augmented renal clearance and how to augment antibiotic dosing
IH Chen, DP Nicolau - Antibiotics, 2020 - mdpi.com
Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly
observed in the critically ill. Its prevalence in this patient population is a consequence of the …
observed in the critically ill. Its prevalence in this patient population is a consequence of the …
[HTML][HTML] Clinical pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for gram-negative infections: an updated review
CJ Hodiamont, AK van den Broek, SL de Vroom… - Clinical …, 2022 - Springer
Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently
used primarily as part of short-term empirical combination therapy. Gentamicin dosing …
used primarily as part of short-term empirical combination therapy. Gentamicin dosing …
Creatinine‐based equations for the adjustment of drug dosage in an obese population
A Bouquegneau, E Vidal‐Petiot… - British journal of …, 2016 - Wiley Online Library
Aim For drug dosing adaptation, the Kidney Disease: Improving Global Outcomes (KDIGO)
guidelines recommend using estimated glomerular filtration rate (eGFR) by the Chronic …
guidelines recommend using estimated glomerular filtration rate (eGFR) by the Chronic …
[HTML][HTML] Aminoglycosides in the intensive care unit: what is new in population PK modeling?
A Duong, C Simard, YL Wang, D Williamson, A Marsot - Antibiotics, 2021 - mdpi.com
Background: Although aminoglycosides are often used as treatment for Gram-negative
infections, optimal dosing regimens remain unclear, especially in ICU patients. This is due to …
infections, optimal dosing regimens remain unclear, especially in ICU patients. This is due to …
Population pharmacokinetic analysis and dosing optimization based on unbound daptomycin concentration and cystatin C in nonobese elderly patients with …
M Samura, K Takada, R Yamamoto, H Ito… - Pharmaceutical …, 2021 - Springer
Purpose This study evaluated the population pharmacokinetics of daptomycin in nonobese
elderly patients with hypoalbuminemia and chronic kidney disease (CKD) using the …
elderly patients with hypoalbuminemia and chronic kidney disease (CKD) using the …
[HTML][HTML] Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C
PKL Chin, DFB Wright, M Zhang, MC Wallace… - Drugs in R&D, 2014 - Springer
Aims Dabigatran is largely cleared by renal excretion. Renal function is thus a major
determinant of trough dabigatran concentrations, which correlate with the risk of …
determinant of trough dabigatran concentrations, which correlate with the risk of …
Population pharmacokinetic study of ceftriaxone in elderly patients, using cystatin C-based estimates of renal function to account for frailty
SJ Tan, M Cockcroft, M Page-Sharp… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Ceftriaxone is widely used for respiratory and urinary infections in elderly and frail patients,
but there are few pharmacokinetic studies. A prospective population pharmacokinetic study …
but there are few pharmacokinetic studies. A prospective population pharmacokinetic study …
Removal of body surface area normalisation improves raw‐measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration …
JSC Chew‐Harris, PKL Chin… - Internal medicine …, 2015 - Wiley Online Library
Abstract Background/Aim We aimed to compared estimated glomerular filtration rate (eGFR)
according to the C hronic K idney D isease E pidemiology C ollaboration equation (CKD …
according to the C hronic K idney D isease E pidemiology C ollaboration equation (CKD …
Gentamicin and renal function: lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin
SM Plajer, PKL Chin, JWA Vella-Brincat… - Therapeutic drug …, 2015 - journals.lww.com
Background: Extended interval dosing (EID) of gentamicin most commonly involves dosing
every 24 hours, but patients with impaired renal function may require a longer dose interval …
every 24 hours, but patients with impaired renal function may require a longer dose interval …
Which patients may benefit from dose adjustment of non-vitamin K antagonist oral anticoagulants?
PKL Chin - Seminars in thrombosis and hemostasis, 2015 - thieme-connect.com
The commercially available non-vitamin K antagonist oral anticoagulants (NOAC) are an
emerging therapeutic class, which includes dabigatran, rivaroxaban, apixaban, and …
emerging therapeutic class, which includes dabigatran, rivaroxaban, apixaban, and …