Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
M Yi, X Zheng, M Niu, S Zhu, H Ge, K Wu - Molecular cancer, 2022 - Springer
Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …
cells from exhausted status and revive immune response against cancer cells. Based on the …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
[HTML][HTML] Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression
KL Owen, NK Brockwell, BS Parker - Cancers, 2019 - mdpi.com
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …
almost all immune regulatory processes, including those that are involved in tumor cell …
cGAS-STING, an important pathway in cancer immunotherapy
M Jiang, P Chen, L Wang, W Li, B Chen, Y Liu… - Journal of hematology & …, 2020 - Springer
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …
MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis
The most prominent homozygous deletions in cancer affect chromosome 9p21. 3 and
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
Dendritic cells and CD8 T cell immunity in tumor microenvironment
C Fu, A Jiang - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell
immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 …
immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 …
[HTML][HTML] Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy
Effector T cells have the capability of recognizing and killing cancer cells. However, whether
tumors can become immune resistant through exclusion of effector T cells from the tumor …
tumors can become immune resistant through exclusion of effector T cells from the tumor …
Manganese coordination micelles that activate stimulator of interferon genes and capture in situ tumor antigens for cancer metalloimmunotherapy
J Li, H Ren, Q Qiu, X Yang, J Zhang, C Zhang, B Sun… - ACS …, 2022 - ACS Publications
Cancer immunotherapy holds great promise but is generally limited by insufficient induction
of anticancer immune responses. Here, a metal micellar nanovaccine is developed by the …
of anticancer immune responses. Here, a metal micellar nanovaccine is developed by the …
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
The recognition of microbial nucleic acids is a major mechanism by which the immune
system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA …
system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA …