Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

The recognition of vitamin C is associated with a history of an unrelenting search for the
cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential …

Ascorbic acid is one of the important water soluble vitamins. It is essential for collagen,
carnitine and neurotransmitters biosynthesis. Most plants and animals synthesize ascorbic …

Reactive oxygen species and reactive nitrogen species are formed in the human body.
Endogenous antioxidant defences are inadequate to scavenge them completely, so that …

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo? Page 1 Free Rad. Res., Vol. 25,
No. 5, pp. Reprints available directly from the publisher Photocopying permitted by license only …

Newborns and particularly preterm infants are at high risk of oxidative stress and they are
very susceptible to free radical oxidative damage. Indeed, there is evidence of an imbalance …

Iron, to be redox cycling active, has to be released from its macromolecular complexes
(ferritin, transferrin, hemoproteins, etc.). Iron is released from hemoglobin or its derivatives in …

BACKGROUND Blood transfusion has been recognised as a risk factor for the development
of retinopathy of prematurity (ROP) or chronic lung disease (CLD) in preterm infants, but the …

Traumatic brain injury (TBI) is the leading cause of morbidity and mortality among children
and both clinical and experimental data reveal that the immature brain is unique in its …

Vitamin C (ascorbic acid, AA) can act as an antioxidant or a pro-oxidant in vitro, depending
on the absence or the presence, respectively, of redox-active metal ions. Some adults with …