The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …

Canonical Wnt signaling plays an important role in development and disease, regulating
transcription of target genes and stabilizing many proteins phosphorylated by glycogen …

Wnt/β-catenin signaling is a branch of a functional network that dates back to the first
metazoans and it is involved in a broad range of biological systems including stem cells …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Tumor cells undergoing the epithelial-mesenchymal transition (EMT) acquire the capacity to
migrate, invade the stroma and metastasize. EMT cells also acquire stem cell characteristics …