Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Traditional imaging modalities such as computed tomography, although perfectly adept at
identifying and quantifying advanced calcification, cannot detect the early stages of this …

The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur
in the organization, composition, and mechanical properties of the extracellular matrix …

Objective—Extensive remodeling of the valve ECM in calcific aortic valve sclerosis alters its
mechanical properties, but little is known about the impact of matrix mechanics on the cells …

Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated
process, increasingly recognized as a general cardiovascular risk factor. Remarkably …

The association of bone pathologies with atherosclerosis has stimulated the search for
common mediators linking the skeletal and the vascular system. Since its initial discovery as …

Objective—Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity
and tracking metabolic syndrome parameters. Ldlr−/− mice fed high-fat “Westernized” diets …

Background—Clinical studies have demonstrated that 50% of individuals with chronic renal
disease (CRD) die of cardiovascular causes, including advanced calcific arterial and …

We tested the hypothesis that carotid artery stiffening with ageing is associated with
transforming growth factor‐β1 (TGF‐β1)‐related increases in adventitial collagen and …

Objectives Conceptually, two types of tertiary dentine may be produced in response to caries
and environmental irritations:“reactionary dentine” that is secreted by existing primary …