Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents

JM Conlon, M Mechkarska, ML Lukic, PR Flatt - Peptides, 2014 - Elsevier
Frog skin constitutes a rich source of peptides with a wide range of biological properties.
These include host-defense peptides with cytotoxic activities against bacteria, fungi …

New insights into amino acid metabolism, β-cell function and diabetes

P Newsholme, L Brennan, B Rubi, P Maechler - Clinical science, 2005 - portlandpress.com
Specific amino acids are now known to acutely and chronically regulate insulin secretion
from pancreatic β-cells in vivo and in vitro. Understanding the molecular mechanisms by …

Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander)

AM Gray, PR Flatt - British Journal of Nutrition, 1999 - cambridge.org
Coriandrum sativum (coriander) has been documented as a traditional treatment of
diabetes. In the present study, coriander incorporated into the diet (62· 5 g/kg) and drinking …

Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by …

JMA Hannan, L Ali, B Rokeya, J Khaleque… - British Journal of …, 2007 - cambridge.org
Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant
treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary …

Antidiabetic food-derived peptides for functional feeding: Production, functionality and in vivo evidences

F Rivero-Pino, FJ Espejo-Carpio, EM Guadix - Foods, 2020 - mdpi.com
Bioactive peptides released from the enzymatic hydrolysis of food proteins are currently a
trending topic in the scientific community. Their potential as antidiabetic agents, by …

[HTML][HTML] The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro

AM Gray, YHA Abdel-Wahab, PR Flatt - The Journal of nutrition, 2000 - Elsevier
Sambucus nigra (elder) has been documented as a traditional treatment of diabetes. In the
present study, an aqueous extract of elder (AEE, 1 g/L) significantly increased 2-deoxy …

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

PA Harnedy, V Parthsarathy, CM McLaughlin… - Food Research …, 2018 - Elsevier
Large quantities of low-value protein rich co-products, such as salmon skin and trimmings,
are generated annually. These co-products can be upgraded to high-value functional …

Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells

JMA Hannan, L Marenah, L Ali… - Journal of …, 2006 - joe.bioscientifica.com
Ocimum sanctum leaves have previously been reported to reduce blood glucose when
administered to rats and humans with diabetes. In the present study, the effects of ethanol …

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

R Carlessi, Y Chen, J Rowlands, VF Cruzat… - Scientific reports, 2017 - nature.com
Abstract Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells
in a glucose dependent manner. Several pathways mediate this action by rapid, kinase …

[PDF][PDF] Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom)

AM Gray, PR Flatt - Journal of Endocrinology, 1998 - medicinacomplementar.com.br
Agaricus campestris (mushroom) has been documented as a traditional treatment for
diabetes. Here the administration of mushroom in the diet (62· 5 g/kg) and drinking water (2 …