CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with
cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in …

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …

Multiple sclerosis (MS) is a complex neurodegenerative disease affecting the central
nervous system (CNS). The onset of MS has been typically observed in individuals aged …

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …

Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ …

It is well established that CD8+ T cells constitute an important branch of adaptive immunity
contributing to clearance of intracellular pathogens and providing long-term protection …

Specific immune suppression and induction of tolerance are essential processes in the
regulation and circumvention of immune defence. The balance between allergen‐specific …