CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential
CH Koh, S Lee, M Kwak, BS Kim… - Experimental & Molecular …, 2023 - nature.com
CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …
Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
RT Manguso, HW Pope, MD Zimmer, FD Brown… - Nature, 2017 - nature.com
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with
cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in …
cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in …
Immunopathology of multiple sclerosis
CA Dendrou, L Fugger, MA Friese - Nature Reviews Immunology, 2015 - nature.com
Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …
point to distinct immunological pathways that drive disease relapses and progression. In …
Multiple sclerosis: Pathology, diagnosis and treatments
WJ Huang, WW Chen, X Zhang - Experimental and …, 2017 - spandidos-publications.com
Multiple sclerosis (MS) is a complex neurodegenerative disease affecting the central
nervous system (CNS). The onset of MS has been typically observed in individuals aged …
nervous system (CNS). The onset of MS has been typically observed in individuals aged …
Monalizumab: inhibiting the novel immune checkpoint NKG2A
T Van Hall, P André, A Horowitz, DF Ruan… - … for immunotherapy of …, 2019 - Springer
The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
CD8+ Regulatory T Cell – A Mystery to Be Revealed
S Mishra, S Srinivasan, C Ma, N Zhang - Frontiers in immunology, 2021 - frontiersin.org
Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …
Opposing T cell responses in experimental autoimmune encephalomyelitis
N Saligrama, F Zhao, MJ Sikora, WS Serratelli… - Nature, 2019 - nature.com
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ …
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ …
Heterogeneity in the Differentiation and Function of CD8+ T Cells
HW Mittrücker, A Visekruna, M Huber - Archivum immunologiae et …, 2014 - Springer
It is well established that CD8+ T cells constitute an important branch of adaptive immunity
contributing to clearance of intracellular pathogens and providing long-term protection …
contributing to clearance of intracellular pathogens and providing long-term protection …
Mechanisms of immune suppression by interleukin‐10 and transforming growth factor‐β: the role of T regulatory cells
A Taylor, J Verhagen, K Blaser, M Akdis… - Immunology, 2006 - Wiley Online Library
Specific immune suppression and induction of tolerance are essential processes in the
regulation and circumvention of immune defence. The balance between allergen‐specific …
regulation and circumvention of immune defence. The balance between allergen‐specific …