Mechanism and regulation of centriole and cilium biogenesis

DK Breslow, AJ Holland - Annual review of biochemistry, 2019 - annualreviews.org
The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Microtubule organization, dynamics and functions in differentiated cells

A Muroyama, T Lechler - Development, 2017 - journals.biologists.com
Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Organization and function of non-dynamic biomolecular condensates

JB Woodruff, AA Hyman, E Boke - Trends in biochemical sciences, 2018 - cell.com
Cells compartmentalize biochemical reactions using organelles. Organelles can be either
membrane-bound compartments or supramolecular assemblies of protein and ribonucleic …

The mechanism of acentrosomal spindle assembly in human oocytes

T Wu, J Dong, J Fu, Y Kuang, B Chen, H Gu, Y Luo… - Science, 2022 - science.org
Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However,
the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

V Joukov, A De Nicolo - Science signaling, 2018 - science.org
Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Meiotic spindle assembly and chromosome segregation in oocytes

I Bennabi, ME Terret, MH Verlhac - Journal of Cell Biology, 2016 - rupress.org
Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth
in the ovary to support development after fertilization. To preserve this cytoplasmic maternal …

[HTML][HTML] A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

DK Breslow, S Hoogendoorn, AR Kopp, DW Morgens… - Nature …, 2018 - nature.com
Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic …

A genetic basis for facultative parthenogenesis in Drosophila

AL Sperling, DK Fabian, E Garrison, DM Glover - Current Biology, 2023 - cell.com
Facultative parthenogenesis enables sexually reproducing organisms to switch between
sexual and asexual parthenogenetic reproduction. To gain insights into this phenomenon …

Assembly and positioning of the oocyte meiotic spindle

B Mogessie, K Scheffler, M Schuh - Annual review of cell and …, 2018 - annualreviews.org
Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual
cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte …

The centrosome and the primary cilium: the yin and yang of a hybrid organelle

V Joukov, A De Nicolo - Cells, 2019 - mdpi.com
Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …