[HTML][HTML] 3D bioprinting photo-crosslinkable hydrogels for bone and cartilage repair

Q Mei, J Rao, HP Bei, Y Liu, X Zhao - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) bioprinting has become a promising strategy for bone
manufacturing, with excellent control over geometry and microarchitectures of the scaffolds …

[HTML][HTML] Bisphosphonate conjugation for bone specific drug targeting

KB Farrell, A Karpeisky, DH Thamm, S Zinnen - Bone reports, 2018 - Elsevier
Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

A Mucha, P Kafarski, Ł Berlicki - Journal of Medicinal Chemistry, 2011 - ACS Publications
R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Targeted delivery to bone and mineral deposits using bisphosphonate ligands

LE Cole, T Vargo-Gogola, RK Roeder - Advanced drug delivery reviews, 2016 - Elsevier
The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Targeting polymer therapeutics to bone

SA Low, J Kopeček - Advanced drug delivery reviews, 2012 - Elsevier
An aging population in the developing world has led to an increase in musculoskeletal
diseases such as osteoporosis and bone metastases. Left untreated many bone diseases …

The role of sphingosine-1-phosphate in bone remodeling and osteoporosis

JM Grewe, PR Knapstein, A Donat, S Jiang, DJ Smit… - Bone Research, 2022 - nature.com
Osteoporosis is a systemic bone disease that affects more than 200 million people
worldwide and is caused by the disruption of the equilibrium between osteoclastic bone …

Recent advances in bone-targeted therapy

C Shi, T Wu, Y He, Y Zhang, D Fu - Pharmacology & therapeutics, 2020 - Elsevier
The coordination between bone resorption and bone formation plays an essential role in
keeping the mass and microstructure integrity of the bone in a steady state. However, this …

Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer

SH Chen, TI Liu, CL Chuang, HH Chen… - Journal of Materials …, 2020 - pubs.rsc.org
To considerably enhance treatment efficacy for bone metastatic breast cancer via dual
bone/tumor-targeted chemotherapy, a nanoparticle-based delivery system comprising poly …

Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer

W Ye, Y Zhao, H Li, R Na, F Li, Q Mei, M Zhao… - Scientific reports, 2015 - nature.com
In order to increase the therapeutic effect of doxorubicin (DOX) on bone metastases, a
multifunctional micelle was developed by combining pH-sensitive characteristics with bone …

Smart bioinks for the printing of human tissue models

Z Maan, NZ Masri, SM Willerth - Biomolecules, 2022 - mdpi.com
3D bioprinting has tremendous potential to revolutionize the field of regenerative medicine
by automating the process of tissue engineering. A significant number of new and advanced …