As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …

Abstract Type 1 diabetes (T1D) is a metabolic disease of unknown aetiology that results from
the autoimmune destruction of the β-cells. Clinical onset with classic hyperglycaemic …

Mental disorders have for the majority of cases an unknown etiology, but several studies
indicate that neurodevelopmental changes happen in utero or early after birth. We …

Exposure to endocrine disrupting chemicals (EDCs) may have implications for the
development of type 1 diabetes mellitus (T1DM), especially if exposure occurs during …

Abstract Aims Interleukin (IL)‐17 is associated with autoimmunity. This study aimed to affirm
the role of IL‐17A, IL‐17F and single nucleotide polymorphisms (SNPs) in genes related to …

Type 1 diabetes mellitus (T1DM) is a complex condition caused by the destruction of
pancreatic beta cells by autoimmune mechanisms. As a result, insulin deficiency and …

Abstract Dipeptidyl-peptidase 4 (DPP-4) inhibitor (sitagliptin) is a novel anti-hyperglycemia
drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still …

Background The prevalence of type 1 diabetes is increasing worldwide, suggesting that
unknown environmental factors are becoming increasingly important in its pathogenesis …

Problem Previous studies have suggested that immune perturbations during pregnancy can
affect offspring type 1 diabetes (T1D) risk. We aimed to identify immunological markers that …

Recent progress in regulatory T cells (Tregs) biology emphasizes the importance of
understanding tissue-resident Tregs in response to tissue-specific environment. Now …