The red flour beetle T. castaneum: elaborate genetic toolkit and unbiased large scale RNAi screening to study insect biology and evolution

M Klingler, G Bucher - EvoDevo, 2022 - Springer
The red flour beetle Tribolium castaneum has emerged as an important insect model system
for a variety of topics. With respect to studying gene function, it is second only to the vinegar …

The quest for the best target genes for RNAi‐mediated pest control

D Cedden, G Bucher - Insect Molecular Biology, 2024 - Wiley Online Library
RNA interference (RNAi) has emerged as an eco‐friendly alternative to classic pesticides for
pest control. This review highlights the importance of identifying the best target genes for …

NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum

MT Naseem, R Beaven, T Koyama… - Proceedings of the …, 2023 - National Acad Sciences
More than half of all extant metazoan species on earth are insects. The evolutionary success
of insects is linked with their ability to osmoregulate, suggesting that they have evolved …

Superior target genes and pathways for RNAi‐mediated pest control revealed by genome‐wide analysis in the beetle Tribolium castaneum

B Buer, J Dönitz, M Milner, S Mehlhorn… - Pest Management …, 2024 - Wiley Online Library
BACKGROUND An increasing human population, the emergence of resistances against
pesticides and their potential impact on the environment call for the development of new eco …

A conserved STRIPAK complex is required for autophagy in muscle tissue

Y Guo, Q Zeng, D Brooks… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
Autophagy is important for cellular homeostasis and to prevent the abnormal accumulation
of proteins. While many proteins that comprise the canonical autophagy pathway have been …

Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle

F Kaufholz, J Ulrich, MS Hakeemi… - Proceedings of the …, 2024 - National Acad Sciences
Animals from all major clades have evolved a segmented trunk, reflected in the human spine
or the insect segments. These units emerge during embryogenesis from a posterior segment …

Persistent Parental RNAi in the Beetle Tribolium castaneum Involves Maternal Transmission of Long Double‐Stranded RNA

T Horn, KD Narov, KA Panfilio - Advanced Genetics, 2022 - Wiley Online Library
Parental RNA interference (pRNAi) is a powerful and widely used method for gene‐specific
knockdown. Yet in insects its efficacy varies between species, and how the systemic …

Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities

J O'Brien, C Mitchell, S Auerbach… - Toxicological …, 2024 - academic.oup.com
There is a pressing need to increase the efficiency and reliability of toxicological safety
assessment for protecting human health and the environment. Although conventional …

Insecticidal proteins and RNAi in the control of insects

AM Vélez, K Narva, M Darlington, S Mishra… - Advances in Insect …, 2023 - Elsevier
RNA interference (RNAi) is a gene-silencing mechanism conserved across Eukaryota
widely used as a research tool to study gene function and, since 2007, investigated for …

[HTML][HTML] BeetleAtlas: An Ontogenetic and Tissue-specific Transcriptomic Atlas of the Red Flour Beetle Tribolium castaneum

DP Leader, MT Naseem, KV Halberg - Journal of Molecular Biology, 2024 - Elsevier
The red flour beetle Tribolium castaneum has emerged as a powerful model in insect
functional genomics. However, a major limitation in the field is the lack of a detailed spatio …