Drug delivery by supramolecular design
The rational design of drug delivery approaches leveraging supramolecular chemistry
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …
Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials
In this review we intend to provide a relatively comprehensive summary of the work of
supramolecular hydrogelators after 2004 and to put emphasis particularly on the …
supramolecular hydrogelators after 2004 and to put emphasis particularly on the …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
Supramolecular biomaterials
Polymers, ceramics and metals have historically dominated the application of materials in
medicine. Yet rationally designed materials that exploit specific, directional, tunable and …
medicine. Yet rationally designed materials that exploit specific, directional, tunable and …
Enzyme-Instructed Intracellular Peptide Assemblies
Conspectus Higher-order or supramolecular protein assemblies, usually regulated by
enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary …
enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary …
Integrating enzymatic self-assembly and mitochondria targeting for selectively killing cancer cells without acquired drug resistance
Targeting organelles by modulating the redox potential of mitochondria is a promising
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …
Enzymatic assemblies disrupt the membrane and target endoplasmic reticulum for selective cancer cell death
The endoplasmic reticulum (ER) is responsible for the synthesis and folding of a large
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …
Designed peptide amphiphiles as scaffolds for tissue engineering
W Sun, DA Gregory, X Zhao - Advances in Colloid and Interface Science, 2023 - Elsevier
Peptide amphiphiles (PAs) are peptide-based molecules that contain a peptide sequence as
a head group covalently conjugated to a hydrophobic segment, such as lipid tails. They can …
a head group covalently conjugated to a hydrophobic segment, such as lipid tails. They can …
Self-assembling peptide-based building blocks in medical applications
Peptides and peptide-conjugates, comprising natural and synthetic building blocks, are an
increasingly popular class of biomaterials. Self-assembled nanostructures based on …
increasingly popular class of biomaterials. Self-assembled nanostructures based on …