Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …

Nerve growth factor (NGF) was first discovered approximately 60 years ago by Rita Levi‐
Montalcini as a protein that induces the growth of nerves. It is now known that NGF is also …

Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However in the adult …

Chronic pain presents a huge economic and social burden, with existing treatments largely
unable to satisfy medical needs. Recently, studies have shown that nerve growth factor …

Neuropathic pain remains one of the most challenging of all neurological diseases and
presents a large unmet need for improved therapies. Many mechanistic details are still …

In the last two decades, nerve growth factor (NGF), initially described as a prototypical
trophic factor in the development of sensory and sympathetic innervation, has emerged as a …

Clinical presentation of osteoarthritis (OA) is dominated by pain during joint use and at rest.
OA pain is caused by aberrant functioning of a pathologically altered nervous system with …

One of the major challenges for cancer therapeutics is the resistance of many tumor cells to
induction of cell death due to pro-survival signaling in the cancer cells. Here we review the …

Nerve growth factor (NGF) is critical for the development and maintenance of sympathetic
and sensory neurons in the developing nervous system, including nociceptors. In the adult …

The neurotrophin nerve growth factor (NGF) has been implicated as a key mediator of
chronic pain. NGF binds the tropomysin receptor kinase A (TrkA) and p75, resulting in the …