Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

Numerous chromatin remodeling enzymes position nucleosomes in eukaryotic cells. Aside
from these factors, transcription, DNA sequence, and statistical positioning of nucleosomes …

SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …

Background A common issue in CRISPR-Cas9 genome editing is off-target activity, which
prevents the widespread use of CRISPR-Cas9 in medical applications. Among other factors …

In order to control gene expression, regulatory DNA variants are commonly designed using
random synthetic approaches with mutagenesis and screening. This however limits the size …

Trinucleotide repeat sequences (TRSs), consisting of 10 unique classes of repeats in DNA,
are members of microsatellites and abundantly and non-randomly distributed in many …

Although nucleosome positioning is key to epigenetic regulation, how the DNA sequence
contributes to positioning remains elusive, especially in the context of transcription direction …

Intratumor heterogeneity is a major factor in cancer treatment and relapse resulting in
subclones that respond differently to local environments and treatment. Traditionally …