Human milk lipids

B Koletzko - Annals of Nutrition and Metabolism, 2017 - karger.com
Human milk lipids provide the infant with energy and essential vitamins, polyunsaturated
fatty acids, and bioactive components. Adding complex lipids and milk fat globule …

Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies

OD Rangel-Huerta, B Pastor-Villaescusa, A Gil - Metabolomics, 2019 - Springer
Introduction Obesity is a disorder characterized by a disproportionate increase in body
weight in relation to height, mainly due to the accumulation of fat, and is considered a …

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

SM Murga-Garrido, Q Hong, TWL Cross, ER Hutchison… - Microbiome, 2021 - Springer
Background There is general consensus that consumption of dietary fermentable fiber
improves cardiometabolic health, in part by promoting mutualistic microbes and by …

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

A Blandin, I Dugail, G Hilairet, M Ponnaiah… - Cell reports, 2023 - cell.com
Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the
development of obesity-related metabolic dysfunctions. This study aims to define mouse …

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats

Y Wang, W Yao, B Li, S Qian, B Wei, S Gong… - … & molecular medicine, 2020 - nature.com
Gut microbiota dysbiosis has a significant role in the pathogenesis of metabolic diseases,
including obesity. Nuciferine (NUC) is a main bioactive component in the lotus leaf that has …

Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

H Al-Sulaiti, I Diboun, MV Agha, FFS Mohamed… - Journal of translational …, 2019 - Springer
Background Obesity is associated with an increased risk of insulin resistance and type 2
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …

Circulating sphingolipids, insulin, HOMA-IR, and HOMA-B: the strong heart family study

RN Lemaitre, C Yu, A Hoofnagle, N Hari, PN Jensen… - Diabetes, 2018 - Am Diabetes Assoc
Experimental studies suggest ceramides may play a role in insulin resistance. However, the
relationships of circulating ceramides and related sphingolipids with plasma insulin have …

Lipid remodeling of adipose tissue in metabolic health and disease

YK Cho, S Lee, J Lee, J Doh, JH Park… - … & Molecular Medicine, 2023 - nature.com
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Extracellular miRNAs as mediators of obesity‐associated disease

BB Brandao, M Lino, CR Kahn - The Journal of physiology, 2022 - Wiley Online Library
Extracellular miRNAs are found in a variety of body fluids and mediate intercellular and
interorgan communication, thus regulating gene expression and cellular metabolism. These …