Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with
symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …

CD8+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and
cancer, characterized by the formation of Slamf6+ progenitor exhausted and Tim-3+ …

Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of
efficacy on early target selection. Drug targets with genetic support are more likely to be …

IL-6 gained much attention with the discovery that this cytokine is a non-redundant
differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses …

The term osteoimmunology describes an interdisciplinary research field that links the
investigation of osteology (bone cells) with immunology. The crosstalk between innate and …

Mutations of the genes encoding T‐cell receptor (TCR)‐proximal signaling molecules, such
as ZAP‐70, can be causative of immunological diseases ranging from T‐cell …

Thymic selection and peripheral activation of conventional T (Tconv) and regulatory T (Treg)
cells depend on TCR signaling, whose anomalies are causative of autoimmunity. Here, we …

Disease-modifying drugs have improved the treatment for autoimmune joint disorders, such
as rheumatoid arthritis, but inflammatory flares are a common experience. This work reports …