Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Gadolinium, an obscure lanthanide element buried in the middle of the periodic table, has in
the course of a decade become commonplace in medical diagnostics. Like platinum in …

There is at present a need in several areas for a ra-tional approach toward ligand design for
selective complexation of metal ions in solution. Such areas would be, for example, design …

The use of radionuclides in medicine is based largely on the discoveries of two critical
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …

Gadolinium is widely known by all practitioners of magnetic resonance imaging (MRI) but
few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent …

The combined experimental and computational study of the 13 magnetic complexes
belonging to the Na [LnDOTA (H2O)](H4DOTA= tetraazacyclododecane-N, N′, N ″, N …

Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

The paramagnetic properties of trivalent lanthanide cations (Ln (II1)) have been exploited in
NMR spectroscopy for a long time. In an early “0 NMR study Lewis et al.[l] utilized Ln (II1) …

The sensitive and specific detection of analytes such as proteins in biological samples is
critical for a variety of applications, for example disease diagnosis. In immunoassays a …