Recently, skeletal muscle represents a complex and challenging tissue to be generated in
vitro for tissue engineering purposes. Several attempts have been pursued to develop …

Classical approaches to engineer skeletal muscle tissue based on current regenerative and
surgical procedures still do not meet the desired outcome for patient applications. Besides …

The synovium of osteoarthritis (OA) patients can be characterized by an abnormal
accumulation of macrophages originating from extravasated monocytes. Since targeting …

Skeletal muscle physiology and the mechanisms of muscle diseases can be effectively
studied by an in-vitro tissue model produced by muscle tissue engineering. Engineered …

Abstract Myotonic dystrophy type 1 (DM1) is the most common hereditary myopathy in the
adult population. The disease is characterized by progressive skeletal muscle degeneration …

The organ-specific metastatization of breast cancer to bone is driven by specific interactions
between the host microenvironment and cancer cells (CCs). However, it is still unclear the …

Over the past years, 3D in vitro models have been widely employed in the regenerative
medicine field. Among them, organ-on-a-chip technology has the potential to elucidate …

During metastatic progression multiple players establish competitive mechanisms, whereby
cancer cells (CCs) are exposed to both pro-and anti-metastatic stimuli. The early metastatic …

Engineering models of human skeletal muscle tissue provides unique translational
opportunities to investigate and develop therapeutic strategies for acute muscle injuries, and …

The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is
influential for the progression of metastases. In particular, the process of extravasation relies …