DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …

Exposure to environmental mutagens but also cell-endogenous processes can create DNA
double-strand breaks (DSBs) in a cell's genome. DSBs need to be repaired accurately and …

Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA
replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress …

Suppression of nascent DNA degradation has emerged as an essential role of the BRCA
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …

Nonhomologous end-joining (NHEJ) factors act in replication-fork protection, restart, and
repair. Here, we identified a mechanism related to RNA: DNA hybrids to establish the NHEJ …

In all the eukaryotic cells, nucleolytic processing (resection) of a double strand DNA break
(DSB) is a key step to channel the repair of the lesion toward the homologous …

Two DNA repair pathways operate at DNA double strand breaks (DSBs): non-homologous
end-joining (NHEJ), that requires two adjacent DNA ends for ligation, and homologous …

BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It
processes distinct DNA substrates, but not nicked DNA, during many steps in DNA …

To maintain genomic stability, the mammalian cells has evolved a coordinated response to
DNA damage, including activation of DNA repair and cell cycle checkpoint processes …

Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational
landscape ('mutator phenotype') of some cancers, however, the basis of this sporadic …