Diabetes mellitus and the impairment of male reproductive function: Possible signaling pathways

S Barkabi-Zanjani, V Ghorbanzadeh, M Aslani… - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims Today, it has been shown that diabetes mellitus (DM) can affect male
fertility. Glucose metabolism is a vital process in spermatogenesis that is impacted by …

[HTML][HTML] An overview of growth factors as the potential link between psoriasis and metabolic syndrome

M Matwiejuk, H Myśliwiec, A Chabowski… - Journal of Clinical …, 2023 - mdpi.com
Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not
only affects the skin, but also the joints and nails. It may coexist with various other disorders …

[HTML][HTML] Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

H Rakhshandeh, H Rajabi Khasevan, A Saviano… - Molecules, 2022 - mdpi.com
Background: Type-one diabetes (T1D), a chronic autoimmune disease with marked
inflammatory responses, is associated with infertility complications and implications. Based …

[HTML][HTML] Hyperglycemia induced testicular damage in type 2 diabetes mellitus rats exhibiting microcirculation impairments associated with vascular endothelial growth …

L Long, H Qiu, B Cai, N Chen, X Lu, S Zheng, X Ye… - Oncotarget, 2018 - ncbi.nlm.nih.gov
As an endocrine disease, type 2 diabetes mellitus (T2DM) can cause testicular damage
which induces male infertility. However, the underlying mechanism is still not clear. We …

Curcumin attenuates testicular injury in rats with streptozotocin‐induced diabetes

W Zha, Y Bai, L Xu, Y Liu, Z Yang… - BioMed Research …, 2018 - Wiley Online Library
Oxidative damage, inflammation, and apoptosis are the primary features of diabetic
testicular damage. Curcumin protects against diabetic testicular injury, but the underlying …

Protective effects of scutellarin on type II diabetes mellitus‐induced testicular damages related to reactive oxygen species/Bcl‐2/Bax and reactive oxygen species …

L Long, J Wang, X Lu, Y Xu, S Zheng… - Journal of diabetes …, 2015 - Wiley Online Library
The goal of our study is to evaluate the effect of Scutellarin on type II diabetes‐induced
testicular disorder and show the mechanism of Scutellarin's action. We used streptozotocin …

[HTML][HTML] Testicular ultrastructure and hormonal changes following administration of tenofovir disoproxil fumarate-loaded silver nanoparticle in type-2 diabetic rats

SO Olojede, SK Lawal, OS Faborode, A Dare… - Scientific Reports, 2022 - nature.com
Reproductive dysfunctions (RDs) characterized by impairment in testicular parameters, and
metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM) are on …

[HTML][HTML] Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells

Z Du, S Xu, S Hu, H Yang, Z Zhou, K Sidhu… - Cell Death & …, 2018 - nature.com
Diabetes mellitus affects a large number of men of reproductive age and it usually leads to
serious reproductive disorders. However, the underlying mechanisms and specific therapies …

[HTML][HTML] Fucoxanthin-rich brown algae extract improves male reproductive function on streptozotocin-nicotinamide-induced diabetic rat model

ZL Kong, S Sudirman, YC Hsu, CY Su… - International Journal of …, 2019 - mdpi.com
Hypogonadism and oxidative stress are occurring commonly in men with diabetes and
associated male infertility. This study aimed to investigate the capability of anti-oxidative and …

Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine

M Abdelmonem, SO Ali, AK Al‐Mokaddem… - …, 2024 - Wiley Online Library
The prevalence of testicular dysfunction is increasing as it is a common diabetes mellites
(DM) complication. The objective of this study is to explore the potential protective effect of …