Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …

Programmed necrosis is a form of caspase-independent cell death whose molecular
regulation is poorly understood. The kinase RIP1 is crucial for programmed necrosis, but …

We report here that mouse macrophages undergo receptor-interacting kinase-3 (RIP3)-
dependent but TNF-α–independent necrosis when Toll-like receptors (TLR) 3 and 4 are …

Smac mimetics induce apoptosis synergistically with TNF-α by triggering the formation of a
caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1) …

Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the
form of death domain receptor engagement by their respective ligands under conditions …

Necrosis has been defined as a type of cell death that lacks the features of apoptosis and
autophagy, and is usually considered to be uncontrolled. Recent research suggests …

Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

Acute pancreatitis is an acute inflammatory process of the pancreas that frequently involves
peripancreatic tissues and at times remote organ systems. The severity of the disease varies …

Objective Acute pancreatitis is caused by toxins that induce acinar cell calcium overload,
zymogen activation, cytokine release and cell death, yet is without specific drug therapy …