GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …

Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory
projection neurons during associative learning has been extensively studied, little is known …

Neocortex is classically divided into distinct areas, each specializing in different function, but
all could benefit from reinforcement feedback to inform and update local processing. Yet it …

Prefrontal cortex (PFC) is postulated to exert" top-down control" on information processing
throughout the brain to promote specific behaviors. However, pathways mediating top-down …

Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play
a key role in the generation of sharp-wave ripples (SWRs), electrophysiological oscillations …

It is still widely thought that cortical projections to distant brain areas derive by and large
from glutamatergic neurons. However, an increasing number of reports provide evidence …

The concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, which
can shape information flow during complex behavioral tasks, has arisen as an important and …

The hippocampus is a multi-stage neural circuit that is critical for memory formation. Its
distinct anatomy has long inspired theories that rely on local interactions between neurons …

Cortical computations are critically reliant on their local circuit, GABAergic cells. In the
hippocampus, a large body of work has identified an unprecedented diversity of GABAergic …