Current and emerging sequencing-based tools for precision cancer medicine
A Edsjö, D Gisselsson, J Staaf, L Holmquist… - Molecular Aspects of …, 2024 - Elsevier
Current precision cancer medicine is dependent on the analyses of a plethora of clinically
relevant genomic aberrations. During the last decade, next-generation sequencing (NGS) …
relevant genomic aberrations. During the last decade, next-generation sequencing (NGS) …
Review of Molecular Technologies for Investigating Canine Cancer
A Kehl, H Aupperle-Lellbach, S de Brot… - Animals, 2024 - mdpi.com
Simple Summary Genetic molecular testing is starting to become part of standard clinical
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …
Molecular analysis of primary and metastatic sites in patients with renal cell carcinoma
BACKGROUND Metastases are the hallmark of lethal cancer, though underlying
mechanisms that drive metastatic spread to specific organs remain poorly understood …
mechanisms that drive metastatic spread to specific organs remain poorly understood …
Assessing DNA Degradation through Differential Amplification Efficiency of Total Human and Human Male DNA in a Forensic qPCR Assay
E Chierto, S Aneli, N Nocco, A Riem, M Onofri… - Genes, 2024 - mdpi.com
The assessment of degradation is crucial for the analysis of human DNA samples isolated
from forensic specimens. Forensic quantitative PCR (qPCR) assays can include multiple …
from forensic specimens. Forensic quantitative PCR (qPCR) assays can include multiple …
Systematic review and feasibility study on pre-analytical factors and genomic analyses on archival formalin-fixed paraffin-embedded breast cancer tissue
Formalin-fixed paraffin-embedded (FFPE) tissue represents a valuable source for
translational cancer research. However, the widespread application of various downstream …
translational cancer research. However, the widespread application of various downstream …
Single Nucleus Total RNA Sequencing of Formalin‐Fixed Paraffin‐Embedded Gliomas
Z Xu, L Chen, X Lin, Y Lyu, M Zhou, H Chen… - Small …, 2024 - Wiley Online Library
Gliomas, the predominant form of brain cancer, comprise diverse malignant subtypes with
limited curative therapies available. The insufficient understanding of their molecular …
limited curative therapies available. The insufficient understanding of their molecular …
Assessment of gene–disease associations and recommendations for genetic testing for somatic variants in vascular anomalies by VASCERN-VASCA
N Revencu, A Eijkelenboom, C Bracquemart… - Orphanet journal of rare …, 2024 - Springer
Background Vascular anomalies caused by somatic (postzygotic) variants are clinically and
genetically heterogeneous diseases with overlapping or distinct entities. The genetic …
genetically heterogeneous diseases with overlapping or distinct entities. The genetic …
[HTML][HTML] Phenotyping Tumor Heterogeneity through Proteogenomics: Study Models and Challenges
D Piana, F Iavarone, E De Paolis, G Daniele… - International Journal of …, 2024 - mdpi.com
Tumor heterogeneity refers to the diversity observed among tumor cells: both between
different tumors (inter-tumor heterogeneity) and within a single tumor (intra-tumor …
different tumors (inter-tumor heterogeneity) and within a single tumor (intra-tumor …
Emerging Approaches to Profile Accessible Chromatin from Formalin-Fixed Paraffin-Embedded Sections
Nucleosomes are non-uniformly distributed across eukaryotic genomes, with stretches of
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …
Paired comparison of the analytical performance between the Oncomine™ Comprehensive Assay v3 and whole-exome sequencing of ovarian cancer tissue
J Lopacinska-Jørgensen, LK Vestergaard… - Molecular Biology …, 2024 - Springer
Background Next-generation sequencing (NGS) has been implemented in clinical oncology
as a personalized medicine tool to identify targetable genetic alterations and to guide …
as a personalized medicine tool to identify targetable genetic alterations and to guide …