Current precision cancer medicine is dependent on the analyses of a plethora of clinically
relevant genomic aberrations. During the last decade, next-generation sequencing (NGS) …

Simple Summary Genetic molecular testing is starting to become part of standard clinical
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …

BACKGROUND Metastases are the hallmark of lethal cancer, though underlying
mechanisms that drive metastatic spread to specific organs remain poorly understood …

The assessment of degradation is crucial for the analysis of human DNA samples isolated
from forensic specimens. Forensic quantitative PCR (qPCR) assays can include multiple …

Formalin-fixed paraffin-embedded (FFPE) tissue represents a valuable source for
translational cancer research. However, the widespread application of various downstream …

Gliomas, the predominant form of brain cancer, comprise diverse malignant subtypes with
limited curative therapies available. The insufficient understanding of their molecular …

Background Vascular anomalies caused by somatic (postzygotic) variants are clinically and
genetically heterogeneous diseases with overlapping or distinct entities. The genetic …

Tumor heterogeneity refers to the diversity observed among tumor cells: both between
different tumors (inter-tumor heterogeneity) and within a single tumor (intra-tumor …

Nucleosomes are non-uniformly distributed across eukaryotic genomes, with stretches of
'open'chromatin strongly associated with transcriptionally active promoters and enhancers …

Background Next-generation sequencing (NGS) has been implemented in clinical oncology
as a personalized medicine tool to identify targetable genetic alterations and to guide …