Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …

In this study, doxorubicin (DOX) was conjugated to a lipophilic triphenylphosphonium (TPP)
that is selectively taken up by the mitochondrial membrane of cells. This new derivative of …

Understanding the interactions of nanoparticles (NPs) with cells and how these interactions
influence their cellular uptake is essential to exploring the biomedical applications of NPs …

Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

Mitochondria-targeted nanoparticles, such as liposomes, polymers and inorganic particles,
suffer from heterogeneity, low biocompatibility and low drug loading efficiency. Here, we …

Mitochondria, the so‐called 'energy factory of cells' not only produce energy but also
contribute immensely in cellular mortality management. Mitochondrial dysfunctions result in …

Mitochondria carry out various essential functions including ATP production, the regulation
of apoptosis and possess their own genome (mtDNA). Delivering target molecules to this …

Doxorubicin, a well‐established chemotherapeutic agent, is known to accumulate in the cell
nucleus. By using ICP‐MS, we show that the conjugation of two small organometallic …

Mitochondrial dysfunctions are recognized as major factors for various diseases including
cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases …