Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Cutaneous squamous cell carcinoma (cSCC), a non-melanoma skin cancer, is a
keratinocyte carcinoma representing one of the most common cancers with an increasing …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans
and its incidence continues to rise. Although CSCC usually display a benign clinical …

Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC
comprises a wide range of tumours originated from diverse anatomical locations that share …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia,
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …

Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its
high incidence and metastatic potential. It may progress from actinic keratosis (AK), a …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

Simple Summary Skin cancers are the most common types of cancer worldwide, and their
incidence is increasing. Epidermal keratinocyte-derived cutaneous squamous cell …