Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

In the cell nucleus, DNA damage signaling and repair machineries operate on a chromatin
substrate, the integrity of which is critical for cell function and viability. Here, we review …

Many CRISPR–Cas (clustered regularly interspaced short palindromic repeats and CRISPR-
associated protein) systems, which provide bacteria with adaptive immunity against phages …

Comparative studies of hominids have long sought to identify mutational events that shaped
the evolution of the human nervous system. However, functional genetic differences are …

Genome editing technologies hold great promise for numerous applications including the
understanding of cellular and disease mechanisms and the development of gene and …

This scoping review examines the use of CRISPR/Cas9 gene editing in glioblastoma (GBM),
a predominant and aggressive brain tumor. Categorizing gene targets into distinct groups …

For precise genome editing via CRISPR/homology-directed repair (HDR), effective and safe
editing of long-term engrafting hematopoietic stem cells (LT-HSCs) is required. The impact …

Gene knockout is a widely used method in biology for investigating gene function. Several
technologies are available for gene knockout, including zinc-finger nuclease technology …

DNA replication requires precise regulation achieved through post-translational
modifications, including ubiquitination and SUMOylation. These modifications are linked by …

Many multidrug-resistant (MDR) bacteria have evolved through the accumulation of
antibiotic resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of …