Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Microbiome in multiple sclerosis: Where are we, what we know and do not know

MK Boziki, E Kesidou, P Theotokis, AFA Mentis… - Brain sciences, 2020 - mdpi.com
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …

Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders

Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …

Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line

A Raasakka, S Ruskamo, J Kowal, R Barker… - Scientific reports, 2017 - nature.com
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ …

S Wang, G Li, X Liang, Z Wu, C Chen… - Advanced …, 2024 - Wiley Online Library
The balance among different CD4+ T cell subsets is crucial for repairing the injured spinal
cord. Dendritic cell (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T …

Development and characterization of a novel conjugated methamphetamine vaccine

MK Hossain, M Davidson, J Feehan, G Deraos… - Vaccine, 2022 - Elsevier
Background Methamphetamine (METH) addiction is a major public health concern globally
with limited management options. The development of a METH vaccine through hapten …

Antigen-specific treatment modalities in MS: The past, the present, and the future

J Derdelinckx, P Cras, ZN Berneman… - Frontiers in …, 2021 - frontiersin.org
Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by
induction of tolerance to a wide range of myelin-derived antigens without hampering the …

Kappa free light chains and IgG combined in a novel algorithm for the detection of multiple sclerosis

M Gudowska-Sawczuk, J Tarasiuk, A Kułakowska… - Brain sciences, 2020 - mdpi.com
Background: It is well known that the cerebrospinal fluid (CSF) concentrations of free light
chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS) …

Recent advances in antigen-specific immunotherapies for the treatment of multiple sclerosis

O Kammona, C Kiparissides - Brain Sciences, 2020 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is
considered to be the leading non-traumatic cause of neurological disability in young adults …

An overview of peptide-based molecules as potential drug candidates for multiple sclerosis

A Del Gatto, M Saviano, L Zaccaro - Molecules, 2021 - mdpi.com
Multiple sclerosis (MS) belongs to demyelinating diseases, which are progressive and
highly debilitating pathologies that imply a high burden both on individual patients and on …