Multiple sclerosis: immunopathology and treatment update
N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …
Microbiome in multiple sclerosis: Where are we, what we know and do not know
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …
and this may be connected to environmental factors. This review article aims to encapsulate …
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders
Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …
Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line
A Raasakka, S Ruskamo, J Kowal, R Barker… - Scientific reports, 2017 - nature.com
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …
Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ …
S Wang, G Li, X Liang, Z Wu, C Chen… - Advanced …, 2024 - Wiley Online Library
The balance among different CD4+ T cell subsets is crucial for repairing the injured spinal
cord. Dendritic cell (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T …
cord. Dendritic cell (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T …
Development and characterization of a novel conjugated methamphetamine vaccine
Background Methamphetamine (METH) addiction is a major public health concern globally
with limited management options. The development of a METH vaccine through hapten …
with limited management options. The development of a METH vaccine through hapten …
Antigen-specific treatment modalities in MS: The past, the present, and the future
J Derdelinckx, P Cras, ZN Berneman… - Frontiers in …, 2021 - frontiersin.org
Antigen-specific therapy for multiple sclerosis may lead to a more effective therapy by
induction of tolerance to a wide range of myelin-derived antigens without hampering the …
induction of tolerance to a wide range of myelin-derived antigens without hampering the …
Kappa free light chains and IgG combined in a novel algorithm for the detection of multiple sclerosis
M Gudowska-Sawczuk, J Tarasiuk, A Kułakowska… - Brain sciences, 2020 - mdpi.com
Background: It is well known that the cerebrospinal fluid (CSF) concentrations of free light
chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS) …
chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS) …
Recent advances in antigen-specific immunotherapies for the treatment of multiple sclerosis
O Kammona, C Kiparissides - Brain Sciences, 2020 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is
considered to be the leading non-traumatic cause of neurological disability in young adults …
considered to be the leading non-traumatic cause of neurological disability in young adults …
An overview of peptide-based molecules as potential drug candidates for multiple sclerosis
A Del Gatto, M Saviano, L Zaccaro - Molecules, 2021 - mdpi.com
Multiple sclerosis (MS) belongs to demyelinating diseases, which are progressive and
highly debilitating pathologies that imply a high burden both on individual patients and on …
highly debilitating pathologies that imply a high burden both on individual patients and on …