Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

Neutrophils are a major component of the innate immune response. Their homeostasis is
maintained, in part, by the regulated release of neutrophils from the bone marrow …

It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer
metastasis was first documented. Since then, the field of chemokines and cancer has grown …

A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

Chemokines (chemo‐attractant cytokines) are a group of small proteins that act together with
their cell surface receptors, in development, normal physiology and immune responses, to …

Signals from the microenvironment have a profound influence on the maintenance and/or
progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived …

Improving approaches for hematopoietic stem cell (HSC) and hematopoietic progenitor cell
(HPC) mobilization is clinically important because increased numbers of these cells are …

The organization of cellular niches is known to have a key role in regulating normal stem cell
differentiation and regeneration, but relatively little is known about the architecture of …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …